Risk and prognostic factors of breast cancer with liver metastases

Abstract Background Liver metastasis is a significant adverse predictor of overall survival (OS) among breast cancer patients. The purpose this study was to determine the risk and prognostic factors with liver metastases (BCLM). Methods Data on 311,573 patients from Surveillance, Epidemiology, End Results (SEER) database 1728 BCLM Fudan University Shanghai Cancer Center (FUSCC) were included. Logistic regression used identify for metastasis. Cox proportional hazards model adopted independent in Young age, invasive ductal carcinoma, higher pathological grade, subtype triple-negative human epidermal growth factor receptor 2 positive (HER2+) developing median OS after 20.0 months SEER 27.3 FUSCC dataset. Molecular subtypes also played critical role We observed that hormone receptor-positive (HR+)/HER2+ had longest (38.0 vs. 34.0 FUSCC), whereas shortest (9.0 15.6 months) both FUSCC. According results FUSCC, HR+/HER2+ (hazard ratio (HR) = 2.62; 95% confidence interval (CI) 1.88–3.66; P < 0.001) HR?/HER2+ (HR 3.43; CI 2.28–5.15; associated significantly increased death comparison HR+/HER2- if these did not receive HER2-targeted therapy. For those who underwent therapy, however, reduced compared 0.74; 0.58–0.95; 0.001). Conclusions Breast at high deserve more attention during follow-up. displayed than due introduction therapy therefore it should be recommended HER2+